Archive for November, 2010

SAMS and Aquapharm sign marine products agreement

Posted On: November 30, 2010

AQUAPHARM Biodiscovery, a leading marine biotechnology company, has announced it has signed a long-term agreement with the Scottish Association for Marine Science (SAMS) to discover, develop and launch new marine products derived from marine micro-organisms.

Under the terms of this agreement, SAMS will provide Aquapharm with privileged access to the vast array of marine samples that it has collected from diverse marine habitats around the globe. Aquapharm will then apply its extensive culturing and marine fermentation know-how to these samples to capture and harness the full microbial biodiversity that they contain, further expanding the scope of its collection of marine micro-organisms.

Once Aquapharm has cultured and identified the range of novel microbial species present in these samples, it will draw out their unique biochemistry through the application of its suite of screening technologies, including SeaRch™, in some cases activating otherwise inaccessible, dormant biosynthetic pathways to produce a cocktail of chemical diversity that Aquapharm will convert into candidate functional ingredients or pharmaceuticals.

More info

US: Newsweek Magazine showcases hunt for medical cures underwater

Posted On: November 24, 2010

Advances in technology are making it easier and increasingly profitable to hunt for drugs in the ocean. Marine bioprospectors, as they’re known, are scouring coral reefs, deep-sea trenches, and everything in between.  David Newman, chief of the natural products branch at the National Cancer Institute (NCI), estimates that at least 30 research teams are experimenting with marine-derived compounds for treating cancer, neural degenerative diseases like Alzheimer’s and Parkinson’s, malaria, diabetes, depression, asthma, and other ailments.

More info

Institute of Chemical Technology (ICT), Matunga, has developed haemostatic biosponge with chitosan

Posted On: November 24, 2010

At first glance, it looks like a piece of thermocol. But, when placed on a profusely bleeding wound, the porous substance can stop bleeding and has the potential to get absorbed in the body without any side effects.

After a three-year research, a two-member team from the Institute of Chemical Technology (ICT), Matunga, has developed a Haemostatic BioSponge, a bio-degradable dressing that is non-toxic and can arrest bleeding.

The team has filed a patent for the product, for which animal trials began 15 days ago at the Bombay Veterinary College, Parel.

“Uncontrolled haemorrhage (bleeding) remains the leading cause of pre-hospital trauma deaths in combat, hospitals and veterinary clinics,” said Kalpesh Chokashi, a PhD student in bioprocess technology. “To date, the preferred intervention for severely bleeding wounds is to apply continuous pressure with a gauze bandage. This is not effective as it does not safely stop severe blood flow.”

At present, the dressing that is used to arrest bleeding is made from either gelatin or chitosan, a non-toxic compound extracted from crab shell, which are then cross-linked with toxic chemicals. The ICT team cross-linked gelatin made from animal bone with chitosan and converted it into foam.

The foam was dried and poured into moulds to form the BioSponge, which was then sterilised with gamma rays.

Apart from stopping blood flow, the BioSponge, which is made of biomaterial, can also be safely absorbed in the body. “A regular gelatin dressing, which is cross linked with toxins, can be harmful if it stays inside the body,” said Professor BN Thorat from the chemical engineering department. The BioSponge can be used as first aid for cuts as well as surgeries.

More info

DSM Creates Effervescent Solution for Omega 3

Posted On: November 24, 2010

DSM Nutritional Products showcased a new omega-3 product featuring its ROPUFA ‘10’ n-3 Food Powder S/SD at the HiE. Delante, a Norwegian company specialising in the development of unique nutritional delivery systems, has developed its Lipidfizz technology using DSM’s powder as the active ingredient. Lipidfizz delivers a high dose of two essential fatty acids in the form of effervescent powders and tablets which are dissolved in water and consumed as a beverage. With a light orange flavour, Lipidfizz meets consumer requirements for a tasty and effective omega-3 product.

DSM’s ROPUFA was the first choice for Delante due to its efficacy and excellent performance with regards to smell and taste. With an advanced formulation, ROPUFA has low oxidisation parameters so does not present the unappealing fishy aftertaste often associated with fish oil. The powder disperses easily in water and is highly stable, making it ideal for use in Delante’s Lipidfizz solution.

More info

Aker BioMarine joins GOED

Posted On: November 24, 2010

Aker BioMarine, has joined the leading marine-sourced omega-3 trade group, the Global Organization for EPA and DHA Omega-3 (GOED). Aker hopes GOED membership will aid krill expansion

In a statement Aker noted the momentum the krill sector had gathered in the past three years – although it remains a miniscule section of the overall omega-3 supply – and its expectation that GOED membership could help build this momentum.

More info

Marine Drugs, Volume 8, Issue 11 (November 2010) now available

Posted On: November 24, 2010

The Office of MDPI AG announces the publication of the following issue: Marine Drugs, Volume 8, Issue 11 (November 2010), Pages 2733-2848 at http://www.mdpi.com/1660-3397/8/11/

Table of Contents:

Adriana Oliveira dos Santos, Phercyles Veiga-Santos, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, Daniela Bueno Sudatti, Éverson Miguel Bianco, Renato Crespo Pereira and Celso Vataru Nakamura

Article: Effect of Elatol, Isolated from Red Seaweed Laurencia dendroidea, on Leishmania amazonensis Mar. Drugs 2010, 8(11), 2733-2743; doi:10.3390/md8112733

http://www.mdpi.com/1660-3397/8/11/2733

Ke Yu, Biao Ren, Junli Wei, Caixia Chen, Jinsheng Sun, Fuhang Song, Huanqin Dai and Lixin Zhang

Article: Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum Mar. Drugs 2010, 8(11), 2744-2754; doi:10.3390/md8112744

http://www.mdpi.com/1660-3397/8/11/2744

Danilo Davyt and Gloria Serra

Review: Thiazole and Oxazole Alkaloids: Isolation and Synthesis Mar. Drugs 2010, 8(11), 2755-2780; doi:10.3390/md8112755

http://www.mdpi.com/1660-3397/8/11/2755

Takeshi Yamamoto

Review: Marine Bacterial Sialyltransferases Mar. Drugs 2010, 8(11), 2781-2794; doi:10.3390/md8112781

http://www.mdpi.com/1660-3397/8/11/2781

Griselda Wilson-Sanchez, Carolina Moreno-Félix, Carlos Velazquez, Maribel Plascencia-Jatomea, Anita Acosta, Lorena Machi-Lara, María-Lourdes Aldana-Madrid, Josafat-Marina Ezquerra-Brauer, Ramón Robles-Zepeda and Armando Burgos-Hernandez

Article: Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei) Mar. Drugs 2010, 8(11), 2795-2809; doi:10.3390/md8112795

http://www.mdpi.com/1660-3397/8/11/2795

Yoel Kashman, Ashgan Bishara and Maurice Aknin

Review: Recent N-Atom Containing Compounds from Indo-Pacific Invertebrates Mar. Drugs 2010, 8(11), 2810-2836; doi:10.3390/md8112810 http://www.mdpi.com/1660-3397/8/11/2810

Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch and Wenhan Lin

Article: Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum Mar. Drugs 2010, 8(11), 2837-2848; doi:10.3390/md8112848

http://www.mdpi.com/1660-3397/8/11/2837

From Issue 12 • Categories: Tags: , No Comments

Chitosan makes the short list for substantiated weight loss / fat modification ingredient, according to recent study

Posted On: November 19, 2010

Scientists from Thomas Jefferson University in Philadelphia and Creighton University in Nebraska performed a review of a range of dietary supplements for weight management and loss, and concluded that the best evidence is in support of CLA, chitosan, pyruvate, and Irvingia gabonensis via fat modifying mechanisms.

Writing in the Journal of Obesity , the reviewers note however that “more data is necessary to draw any definitive conclusions on the use of dietary supplements for weight loss”.

More info

PolyU-Peking U joint research breaks new ground in synthesis of marine natural product anti-cancer agents

Posted On: November 19, 2010

An anti-cancer research jointly conducted by The Hong Kong Polytechnic University (PolyU) and Peking University Shenzhen Graduate School (PKUSZ) has led to the first total synthesis of an anti-cancer marine natural product, grassypeptolide. Not only was this important finding featured on the inside front cover of the authoritative journal Chemical Communications [Issue 40, Volume 46, (2010)], but also highlighted by Nature China.
This cutting-edge research has combined the effort of two research teams from PolyU and PKUSZ, both working under the leadership of Principal Investigator Dr Tao YE (葉濤), Associate Professor of PolyU’s Department of Applied Biology and Chemical Technology. This breakthrough has paved the way for further development of anti-cancer drugs from this natural product grassypeptolide — a compound isolated from a marine bacteria — which has recently emerged as a promising anti-cancer agent.

Despite its fascinating features, grassypeptolide was barely available from natural sources. But now it can be constructed by total chemical synthesis in 17 steps with this breakthrough. The key challenges in the total synthesis of grassypeptolide are the forming of the 31-member ring of grassypeptolide and the introducing of the two smaller thiazoline heterocycles — five-member rings containing sulphur and nitrogen — into the 31-member ring. The researchers constructed the 31-membered macrocycle via a precursor with more favorable cyclization kinetics; and introduced the thiazoline heterocycles at a later stage of the synthesis to prevent the thiazoline heterocycles from undergoing side reactions.

More info

Enzymotec selects DKSH for krill oil distribution

Posted On: November 18, 2010

Zurich-based DKSH has announced an expansion of its agreement with Israel’s Enzymotec to include the distribution of krill oil, as the companies continue their ‘very successful partnership’.

DKSH, which claims to be the ‘number 1 market expansion services provider with a focus on Asia’, said the agreement will also help it to support Enzymotec to expand their food supplement business in the near future to other territories.

The new agreement, which continues “the very successful partnership for distribution of Enzymotec’s phosphor lipid based APIs and excipients”, said DKSH, and the distribution will be led by DKSH’s Business Unit Performance Materials.

More info

GC Rieber expands omega-3 capacity

Posted On: November 18, 2010

Norwegian omega-3 supplier GC Rieber Oils is ready to open facilities that boost its production capacity and quality as it eyes the pharma and medical industries.

The new plant is GMP (Good Manufacturing Practice) and API (Active Pharmaceutical Ingredient) certified and utilises a patented refining technology.

“We have used all of our experience as producers of refined fish oils, and applied it into the construction and design of our new concentrate plant,” said says ex-chief executive officer, Arne Alnæs, who has become director of sourcing and been replaced by Jan Roger Bjerkestrand.

“Our goal is to enter into new markets with omega-3 and we believe we will achieve this with our new ultra-high grade 90 per cent omega-3 fish oil.”

GC Rieber’s omega-3 oils are typically used in food supplements, cosmetics, animal feed and functional foods and are sourced from cod liver, tuna and salmon oils.

More info

 
Follow Me on Twitter