Marinova had also been “inundated with requests from Japan [where fucoidan is well-established] as they are concerned about their own seaweed supply due to possible radioactive contamination”, revealed business development manager Kevin Krail.
Streamline Automation, of Huntsville, Alabama, has been assigned a patent (8,303,818) developed by four co-inventors for a “method and apparatus using an active ionic liquid for algae biofuel harvest and extraction.” The co-inventors are Roberto Di Salvo, Madison, AL, Alton Reich, Huntsville, AL, H. Waite H. Dykes Jr., Huntsville, AL, and Rodrigo Teixeira, Madison, AL.
The abstract of the patent published by the U.S. Patent and Trademark Office states: “The invention relates to use of an active ionic liquid to dissolve algae cell walls. The ionic liquid is used to, in an energy efficient manner, dissolve and/or lyse algae cell walls, which releases algae constituents used in the creation of energy, fuel, and/or cosmetic components. The ionic liquids include ionic salts having multiple charge centers, low, very low, and ultra low melting point ionic liquids, and combinations of ionic liquids.
This spring has seen large extremes in weather patterns from drought to flooding, causing stress to arable crops. But one researcher at University College, Cork, believes a certain chemical found in seaweed could make crops more stress tolerant.
Along with factors such as extremes of temperature, inadequate nutrient supply and excess light intensity fall under the general term of abiotic stress, which can reduce yields by up to 82%.
And a team of researchers at the School of Biological, Earth and Environmental Sciences (BEES) at University College, Cork in Ireland, have been researching stress tolerance by plants. In particular, managing abiotic stress, the mechanisms, chemical or genetic, by which the responses to crop stress can be improved.
One approach being investigated is applying Ascophyllum nodosum seaweed extract and this has been trialled in forage maize, spring barley, oilseed rape and maincrop potatoes.
The first phase of the expansion of the Acadian Seaplants Ltd. plant in Cornwallis Park is nearing completion.
Jean-Paul Deveau, president of the Dartmouth marine biotechnology company, said the first phase of its $4-million, multi-year expansion of its operation in the Annapolis County community began earlier this year and will be completed within the next month or two.
The expansion, to be done in phases, involves buying and upgrading a bigger plant on Conestoga Street, across from Acadian Seaplants’ existing facility. That will allow the company to expand its operation from 15,000 square feet to 100,000 square feet.
“The final step of one of the product lines will now be done at the new facility, and we will pipe intermediate product across from one facility to the other, as they are across the street from each other,” Deveau said.
Growing International Interest In Oceanology To Benefit The Global Marine Biotechnology Market, According To New Report By Global Industry Analysts, Inc.Posted On: April 24, 2012
With growing environmental pollution throwing the spotlight on sustainable industrial development, there exists huge demand for suitable, scalable, economically, socially and environmentally sustainable feedstock options for the manufacturing industry. With sustainable feedstock production and delivery ballooning into a massive industry worldwide, the world’s oceans have emerged into the next frontier for investigative, biological resource development and management R&D projects.
For instance, marine-derived cosmetic ingredients, marine-derived molecules including enzymes, biopolymers and biomaterials, marine-derived pharmaceuticals, among others, are now becoming the mainstay of most R&D projects worldwide. The marine biotechnology sector is also attracting increased venture capital funds as is mirrored by the mushrooming of potential laden start-up firms focused on developing novel compounds from marine organisms.
As stated by the new market research report on Marine Biotechnology, Bioactive Substances represents one of the fastest growing market sectors trailing a projected CAGR of approximately 4.7% respectively.
The research report titled “Marine Biotechnology: A Global Strategic Business Report” announced by Global Industry Analysts Inc., provides a comprehensive review of the marine biotechnology markets, impact of recession on the markets, current market trends, key growth drivers, recent product introductions, recent industry activity, and profiles of major/niche global as well as regional market participants.
Sapphire Energy Inc., which uses a proprietary process to turn algae oil into renewable gasoline to replace fossil fuels at the pump, broke ground last June on a 300-acre commercial demonstration facility in Columbus.
In Hobbs, in the heart of southeast New Mexico’s oil patch, Massachusetts-based Joule Unlimited Inc. broke ground this fall on a five-acre site that will use concentrating-solar biorefineries to extract ethanol and diesel from bacteria in salt-water mixed with carbon dioxide.
Marinova has some exciting news to report in the area of new clinical trials. Reflecting a commitment to developing novel fucoidan compounds with proven therapeutic efficacy, they have just commenced two new clinical trials. These two studies will investigate the potential of Maritech® fucoidan in the following clinical settings:
• Osteoarthritis and Inflammation
This is a large multi-site trial, directly commissioned by Marinova, to assess the ability of Maritech® fucoidan to reduce the symptoms of osteoarthritis. The trial is double randomised, placebo controlled and – in addition to pain score testing – serum samples will be tested for several key markers of inflammation. This study is being conducted at Southern Cross University (Australia) and results are expected in the second quarter of 2012.
• Integrative Oncology
At two centres in Australia, cancer patients undergoing chemotherapy for breast cancer will take Maritech® fucoidan. The levels of chemotherapy drug in serum will be measured to assess the effects of fucoidan, including any interactions with the chemotherapy drug. Indicators of pain and improvements in quality of life will also be assessed. This study is being conducted in conjunction with the University of Tasmania and is scheduled for completion at the end of 2013.
Australian biotech firm Marinova has reported “exceptional” demand in the US and Asia for its fucoidans, bioactives from brown seaweed researchers believe could help to explain the health and longevity of the Japanese.While fucoidans were relatively new entrants to the US market, there was a “small but growing” body of science about their benefits, covering everything from anti-viral and anti-inflammatory effects to stem cell modulation, Marinova told NutraIngredients-USA.com.
Carotenoids have been shown to have beneficial health effects such as pro-vitamin A activity, immune response modulation and anti carcinogenic activity. People consuming diets rich in carotenoids from natural foods, such as fruits and vegetables, are healthier and have lower mortality from a number of chronic illnesses. (cite: Functional food science and defence against reactive oxidative species, British Journal of Nutrition 1998, 80, Suppl. 1, S77–S112).
Fucoxanthin is a major marine carotenoid found in edible seaweeds such as Undaria pinnatifida, commonly known as Wakame. Fucoxanthin also has anti-carcinogenic effects, apoptotic effects in cancer cells, anti-inflammatory effects and radical scavenging activity.
A study conducted by researchers at the University Research & Development in Vlaardingen, Netherlands, has revealed that seaweed reduces the appetite and makes one slim. According to the study, adding seaweed extract alginate to a chocolate milkshake reduces hunger among people by nearly 30 per cent. The details of the study have been published in the journal Obesity.
The researchers, for the study recruited a group of 23 healthy volunteers. These volunteers consumed drink containing various levels of alginate in place of a meal. They reported that their levels of hunger reduced and over the next five hours they felt fullness. Moreover, the alginate didn’t alter the flavor of the shake. The participants said that it was just as pleasant as the real thing.
According to the researchers, alginate turns into a gel in the acidic environment of the stomach, and the calcium adds to the gel’s thickness which creates a feeling of fullness, as well as holds food in the stomach for longer.
Background: Isolated fucoidans from brown marine algae have been shown to have a range of anti-inflammatory effects.
Purpose: This present study tested a Maritech® extract formulation, containing a blend of extracts from three different species of brown algae, plus nutrients in an open label combined phase I and II pilot scale study to determine both acute safety and efficacy in osteoarthritis of the knee.
Results & Conclusions: Eleven participants completed 12 weeks and one completed 10 weeks of the study. Using a multilevel linear model, the average COAT score was reduced by 18% for the 100 mg treatment and 52% for the 1000 mg dose at the end of the study. There was a clear dose response effect seen between the two treatments (P≤0.0005) on the average COAT score and each of the four COAT subscales (pain, stiffness, difficulty with physical activity and overall symptom severity) (P≤0.05).
The seaweed extract nutrient complex when taken orally over twelve weeks decreased the symptoms of osteoarthritis in a dose-dependent manner. It was demonstrated to be safe to use over the study period at the doses tested. The efficacy of the preparation now needs to be demonstrated in a phase III randomized controlled trial (RCT).
Citation: Myers, SP, O’Connor, J, Fitton, JH, Brooks, LO, Rolfe, MI, Connellan, PA, Wohlmuth, H, Cheras, PA & Morris, CA 2010, ‘A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis’, Biologics: Targets and Therapy, vol. 4, pp. 33-44.