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Mar. Drugs, Volume 9, Issue 11 (November 2011), Pages 2164-2487 released
Posted On: December 4, 2011MDPI announces the publication of the following issue: Mar. Drugs, Volume 9, Issue 11 (November 2011), Pages 2164-2487 at http://www.mdpi.com/1660-3397/9/11/
Table of Contents:
Leda Giannuzzi, Daniela Sedan, Ricardo Echenique and Dario Andrinolo
Case Report: An Acute Case of Intoxication with Cyanobacteria and Cyanotoxins in Recreational Water in Salto Grande Dam, Argentina
Mar. Drugs 2011, 9(11), 2164-2175; doi:10.3390/md9112164
http://www.mdpi.com/1660-3397/9/11/2164/
Gi-Young Kim, Wun-Jae Kim and Yung Hyun Choi
Review: Pectenotoxin-2 from Marine Sponges: A Potential Anti-Cancer Agent—A Review
Mar. Drugs 2011, 9(11), 2176-2187; doi:10.3390/md9112176
http://www.mdpi.com/1660-3397/9/11/2176/
Renan Oliveira Silva, Geice Maria Pereira dos Santos, Lucas Antonio Duarte Nicolau, Larisse Tavares Lucetti, Ana Paula Macedo Santana, Luciano de Souza Chaves, Francisco Clark Nogueira Barros, Ana Lúcia Ponte Freitas, Marcellus Henrique Loiola Ponte Souza and Jand-Venes Rolim Medeiros
Article: Sulfated-Polysaccharide Fraction from Red Algae Gracilaria caudata Protects Mice Gut Against Ethanol-Induced Damage
Mar. Drugs 2011, 9(11), 2188-2200; doi:10.3390/md9112188
http://www.mdpi.com/1660-3397/9/11/2188/
Oded Bergman, Boaz Mayzel, Matthew A. Anderson, Muki Shpigel, Russell T. Hill and Micha Ilan
Article: Examination of Marine-Based Cultivation of Three Demosponges for Acquiring Bioactive Marine Natural Products
Mar. Drugs 2011, 9(11), 2201-2219; doi:10.3390/md9112201
http://www.mdpi.com/1660-3397/9/11/2201/
Francisco Cen Pacheco, Janny A. Villa-Pulgarin, Faustino Mollinedo, Manuel Norte Martín, José Javier Fernández and Antonio Hernández Daranas
Article: New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
Mar. Drugs 2011, 9(11), 2220-2235; doi:10.3390/md9112220
http://www.mdpi.com/1660-3397/9/11/2220/
Carla Pereira, Yolanda J. Silva, Ana L. Santos, Ângela Cunha, Newton C. M. Gomes and Adelaide Almeida
Article: Bacteriophages with Potential for Inactivation of Fish Pathogenic Bacteria: Survival, Host Specificity and Effect on Bacterial Community Structure
Mar. Drugs 2011, 9(11), 2236-2255; doi:10.3390/md9112236
http://www.mdpi.com/1660-3397/9/11/2236/
Saveetha Kandasamy, Di Fan, Jatinder Singh Sangha, Wajahatullah Khan, Franklin Evans, Alan T. Critchley and Balakrishnan Prithiviraj
Article: Tasco®, a Product of Ascophyllum nodosum, Imparts Thermal Stress Tolerance in Caenorhabditis elegans
Mar. Drugs 2011, 9(11), 2256-2282; doi:10.3390/md9112256
http://www.mdpi.com/1660-3397/9/11/2256/
Toshiaki J. Hara
Review: Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes
Mar. Drugs 2011, 9(11), 2283-2290; doi:10.3390/md9112283
http://www.mdpi.com/1660-3397/9/11/2283/
Kelvin Sze-Yin Leung, Bonnie Mei-Wah Fong and Yeuk-Ki Tsoi
Review: Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS
Mar. Drugs 2011, 9(11), 2291-2303; doi:10.3390/md9112291
http://www.mdpi.com/1660-3397/9/11/2291/
Ruiyue Yang, Junbo Wang, Zhigang Liu, Xinrong Pei, Xiaolong Han and Yong Li
Article: Antioxidant Effect of a Marine Oligopeptide Preparation from Chum Salmon (Oncorhynchus keta) by Enzymatic Hydrolysis in Radiation Injured Mice
Mar. Drugs 2011, 9(11), 2304-2315; doi:10.3390/md9112304
http://www.mdpi.com/1660-3397/9/11/2304/
Narlize Silva Lira, Ricardo Carneiro Montes, Josean Fechine Tavares, Marcelo Sobral da Silva, Emidio V. L. da Cunha, Petronio Filgueiras de Athayde-Filho, Luis Cezar Rodrigues, Celidarque da Silva Dias and Jose Maria Barbosa-Filho
Review: Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their13C NMR Spectral Data
Mar. Drugs 2011, 9(11), 2316-2368; doi:10.3390/md9112316
http://www.mdpi.com/1660-3397/9/11/2316/
Adriana Oliveira dos Santos, Elizandra Aparecida Britta, Everson Miguel Bianco, Tania Ueda-Nakamura, Benedito Prado Dias Filho, Renato Crespo Pereira and Celso Vataru Nakamura
Article: 4-Acetoxydolastane Diterpene from the Brazilian Brown Alga Canistrocarpus cervicornis as Antileishmanial Agent
Mar. Drugs 2011, 9(11), 2369-2383; doi:10.3390/md9112369
http://www.mdpi.com/1660-3397/9/11/2369/
Vincent Chung-Him Yu, Peter Hoi-Fu Yu, Kin-Chung Ho and Fred Wang-Fat Lee
Article: Isolation and Identification of a New Tetrodotoxin-Producing Bacterial Species, Raoultella terrigena, from Hong Kong Marine Puffer Fish Takifugu niphobles
Mar. Drugs 2011, 9(11), 2384-2396; doi:10.3390/md9112384
http://www.mdpi.com/1660-3397/9/11/2384/
Jessica Ponder, Byong Hoon Yoo, Adedoyin D. Abraham, Qun Li, Amanda K. Ashley, Courtney L. Amerin, Qiong Zhou, Brian G. Reid, Philip Reigan, Robert Hromas, Jac A. Nickoloff and Daniel V. LaBarbera
Article: Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition
Mar. Drugs 2011, 9(11), 2397-2408; doi:10.3390/md9112397
http://www.mdpi.com/1660-3397/9/11/2397/
Matti Vornanen, Minna Hassinen and Jaakko Haverinen
Article: Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Mar. Drugs 2011, 9(11), 2409-2422; doi:10.3390/md9112409
http://www.mdpi.com/1660-3397/9/11/2409/
Samuel Abbas, Michelle Kelly, John Bowling, James Sims, Amanda Waters and Mark Hamann
Review: Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
Mar. Drugs 2011, 9(11), 2423-2437; doi:10.3390/md9112423
http://www.mdpi.com/1660-3397/9/11/2423/
Dioli Ann Payo, Joannamel Colo, Hilconida Calumpong and Olivier de Clerck
Article: Variability of Non-Polar Secondary Metabolites in the Red Alga Portieria
Mar. Drugs 2011, 9(11), 2438-2468; doi:10.3390/md9112438
http://www.mdpi.com/1660-3397/9/11/2438/
Simon P. B. Ovenden, Jonathan L. Nielson, Catherine H. Liptrot, Richard H. Willis, Dianne M. Tapiolas, Anthony D. Wright and Cherie A. Motti
Short Note: A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
Mar. Drugs 2011, 9(11), 2469-2478; doi:10.3390/md9112469
http://www.mdpi.com/1660-3397/9/11/2469/
Cheng-Hai Gao, Yi-Fei Wang, Shen Li, Pei-Yuan Qian and Shu-Hua Qi
Article: Alkaloids and Sesquiterpenes from the South China Sea Gorgonian Echinogorgia pseudossapo
Mar. Drugs 2011, 9(11), 2479-2487; doi:10.3390/md9112479
http://www.mdpi.com/1660-3397/9/11/2479/
Health Enhancement Products, Inc. expands scientific inquiry at Battelle as algae-derived molecules are tested for bioactivity
Posted On: November 27, 2011The board directors of Health Enhancement Products, Inc. (OTCBB: HEPI), a Scottsdale, AZ-based food ingredients and nutraceutical enterprise, has authorized an expanded study of its algae extracts. Since May of 2011, the Company has been working with Battelle, the world’s largest independent research and development organization, to isolate the active molecules in its proprietary algae extract, specifically those natural compounds responsible for supporting a healthy cholesterol balance. Over the intervening months, Battelle research scientists have conducted a series of experiments to separate bioactive fractions of the algae extract in order to isolate and further characterize the bioactive components.
That program has resulted in a number of isolates that can now be tested in vivo. The in vivo portion of this expanded research project will be carried out in several steps. The in vivo study is expected to commence in several days. The isolated samples will be administered to test subjects over the course of 30 days, after which an evaluation process would identify those samples with bioactivity. Battelle scientists would subject those samples to further refinement and validation, or proceed directly to a final analysis.
Norwegian Prawns to Spice Up Chinese Noodles
Posted On: October 14, 2011Bioprospecting is opening up international markets for Norwegian seafood companies. Essences extracted from a prawn or octopus off the west coast of Norway could end up as flavouring in noodle packages in China.
This type of bioprospecting involves investigating marine organisms to find components or compounds that have commercial use. The potential results are particularly promising in relation to foodstuffs as well as for applications in medicine and the energy industry.
In the initial phase, researchers will be investigating various species and raw materials, including species already common in fisheries, untapped resources such as woodlice, and by-products such as leftovers from processing in the fishing industry, to cater for Chinese preferences.
Aquapharm and CABI sign collaborative agreement
Posted On: October 6, 2011Scottish marine biotechnology firm Aquapharm has signed an agreement with the Centre for Agricultural Bioscience International (CABI) which will allow the organisations to access and co-promote one another’s unique microbe collections.
Aquapharm specialises in the discovery, isolation and development of novel functional active ingredients, sustainably harvested from marine micro-organisms for potential use in a wide range of commercial sectors.
Meanwhile not-for-profit organisation CABI – which is highly respected for its cutting-edge research – applies scientific expertise to solve problems in agriculture and the environment, with a focus on scientific publishing, development and research, and microbial services.
The agreement sets out how Aquapharm and CABI will share know-how and resources, paving the way for the future commercialisation of a variety of microbial strains/extracts.
UK University Research Group seeks SME partners to explore the development of three specific marine bio-resources to produce high value products: anti-cancer drugs, oxygenase biocatalysts, anti-microbials
Posted On: September 4, 2011The marine environment is a very rich source of bio-molecules with therapeutic applications. Blue biotechnology specifically seeks to harness the biodiversity of the marine environment for access to high-value and relatively low-volume biological products. Recent advances in molecular biology (including metagenomic methods) mean that there is now remarkable potential to harness genetic biodiversity from specific marine environments for bio-product preparation. For example, when studying marine bacteria they are no longer limited to experimental approaches that focus on the <1% of organisms that can be easily cultivated as pure cultures in the laboratory.
The valorization of marine biodiversity for the EU economy using such approaches therefore offers much promise. In this project they will aim to explore the development of three specific marine bio-resources to produce high value products:
i) Anti-cancer drugs from sponges
ii) Oxygenase biocatalysts from marine bacteria
iii) Anti-microbials based on bacterial viruses
Technical Specifications / Specific technical requirements:
Call Details: KBBE.2012.3.2-01 Innovative marine biodiscovery pipelines for novel industrial products, call deadline 15th November 2011.
Expected proposal budget around ¬5m. Funding for SMEs at 75%
Proposal under prepartion, consotrium academic members in place, SMEs being recruited.
Marine Biotechnology Center of North Carolina breaks ground this week
Posted On: September 4, 2011UNCW’s MARBIONC Center, or the Marine Biotechnology Center of North Carolina, will break ground the first week of September at the Center for Marine Science.
For students in the marine biotechnology program, this could mean big opportunities.
“Students will have the chance to do research that could result in permanent future employment,” said Dr. Jeffery Wright of the Marine Science department.
The center will also help set UNCW’s marine biotechnology students on a path for success.
“The MARBIONC will prepare students for careers in biotechnology and transform how we traditionally approach educating future marine scientists,” said Kevin Zelnio, an independent scientist and assistant editor of Deep Sea News. “It recognizes there is an industry for students that combines very useful research with a marine science education.”
Other hopes for the center include job creation and spinoff companies.
But the main goal of the center is to develop new products and commercialize them.
The 3rd “Rendez-vous de Concarneau”: “Where Industry meets Science in Marine Biotechnology” 30-31 August 2011, France
Posted On: July 7, 2011The ‘Rendez-vous de Concarneau’ constitutes a series of workshops aiming at promoting relationships and strengthening bridges between Industry and academic research, and further at providing technology and knowledge transfer among stakeholders within European marine biotechnologies.
New Astec Centre in UK to offer new opportunities for fledgling marine businesses
Posted On: June 2, 2011The recent opening of the Astec Centre is expected to offer a number of opportunities for fledgling marine businesses.
Astec Aquaculture Business & Science Centre is a purpose-built resource that has been created to support the growth of the aquaculture sector. It opened its doors to businesses and researchers recently, showcasing the extensive facilities and support services that it offers.
Due to its strategic location on the Northumberland coastline at Lyne Sands, Astec is uniquely placed to pump a constant supply of near tropical temperature, flow-through seawater to its state-of-the-art aqua laboratories, which are fitted out with specialist equipment to support a broad range of commercial and research activities.
The new Astec Centre is located close by the Dove Marine Laboratory at Newcastle University, considered a key centre for Newcastle University’s School of Marine Science and Technology, which is leading research into areas such as algae biofuels. However, the prospect of state-of-the-art facilities nearby could help experts refine and expand discoveries further.
Dove Marine Laboratory director Professor Grant Burgess said: “We have several early-stage projects which we may be able to commercialise over the next 12 months. These involve growing and harvesting marine microalgae to make useful products such as omega 3 oils. Astec offers the expertise, historical track record and passion of the people involved to ensure this project is a success.”
The focus at the centre is on application of marine science to building businesses and creating jobs. This complements and builds on current marine biotechnology programmes at the Dove and will considerably strengthen the region in this growth area.
e info
7th European Conference on Marine Natural Products in August ’11
Posted On: May 19, 2011Time: 14 – 18 August, 2011
Place: Strömstad, Sweden
Organizer: The Phytochemical Society of Europe and the Division of Pharmacognosy at Uppsala University
This conference is the 7th in a series of meetings in the area of marine natural product research which are organized every second year by European researchers. Professor Lars Bohlin and co-workers have received the honorary mission that for the first time be responsible for organization of 7ECMNP in Sweden.
The conference will take place in Strömstad in close collaboration between Department of Medicinal Chemistry, Uppsala University, and Sven Lovén Center, Gothenburg University.
The conference is focused on international research in the area of marine natural product research with emphasis on biodiversity in the sea. The different scientific sessions during the congress are focused on biodiversity, biological activity, structure, informatics, and systems biology.
Genome of Marine Organism Reveals Hidden Secrets
Posted On: May 13, 2011An international team of researchers led by scientists at Scripps Institution of Oceanography at UC San Diego has deciphered the genome of a tropical marine organism known to produce substances potentially useful against human diseases.
Tiny photosynthetic microorganisms called cyanobacteria are some of the oldest forms of life on the planet. At times their emergence as toxic blooms causes a threat to humans and animals. But despite the recognized capability of marine strains of the cyanobacterial genus Lyngbya, and specifically the species L. majuscula, to create hundreds of natural products with biomedical promise, surprisingly little is known about the genetics underlying their production.
In this week’s online early edition of the Proceedings of the National Academy of Sciences, a research team led by Scripps graduate student Adam Jones and postdoctoral fellow Emily Monroe, both in the Gerwick laboratory at Scripps Institution of Oceanography’s Center for Marine Biotechnology and Biomedicine (CMBB), provide the first insights of the genome of Lyngbya majuscula 3L, a Caribbean organism that generates compounds that are being developed for potential treatment against cancer and neurodegenerative diseases.
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