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Marine Drugs, Volume 11, Issue 3 (March 2013), Pages Pages 581-974 Now Available
Posted On: April 3, 2013MDPI has announced the publication of the following issue:
Mar. Drugs, Volume 11, Issue 3 (March 2013), Pages Pages 581-974
Table of Contents:
Ophelia Han
Editorial: Marine Drugs Best Paper Award 2013
Mar. Drugs 2013, 11(3), 581-583; doi:10.3390/md11030581
http://www.mdpi.com/1660-3397/11/3/581/
Marco Pelin, Sabrina Boscolo, Mark Poli, Silvio Sosa, Aurelia Tubaro and Chiara Florio
Article: Characterization of Palytoxin Binding to HaCaT Cells Using a Monoclonal Anti-Palytoxin Antibody
Mar. Drugs 2013, 11(3), 584-598; doi:10.3390/md11030584
http://www.mdpi.com/1660-3397/11/3/584/
Jean-Baptiste Gallé, Barthélémy Attioua, Marcel Kaiser, Anne-Marie Rusig, Annelise Lobstein and Catherine Vonthron-Sénécheau
Article: Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum
Mar. Drugs 2013, 11(3), 599-610; doi:10.3390/md11030599
http://www.mdpi.com/1660-3397/11/3/599/
Soohyun Um, Yuna Pyee, Eun-Hee Kim, Sang Lee, Jongheon Shin and Dong-Chan Oh
Article: Thalassospiramide G, a New γ-Amino-Acid-Bearing Peptide from the Marine BacteriumThalassospira sp.
Mar. Drugs 2013, 11(3), 611-622; doi:10.3390/md11030611
http://www.mdpi.com/1660-3397/11/3/611/
Gerrit Gerwig, Henry Hocking, Reto Stöcklin, Johannis Kamerling and Rolf Boelens
Review: Glycosylation of Conotoxins
Mar. Drugs 2013, 11(3), 623-642; doi:10.3390/md11030623
http://www.mdpi.com/1660-3397/11/3/623/
Anna Carbone, Barbara Parrino, Paola Barraja, Virginia Spanò, Girolamo Cirrincione, Patrizia Diana, Armin Maier, Gerhard Kelter and Heinz-Herbert Fiebig
Article: Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin
Mar. Drugs 2013, 11(3), 643-654; doi:10.3390/md11030643
http://www.mdpi.com/1660-3397/11/3/643/
Diego Orts, Steve Peigneur, Bruno Madio, Juliana Cassoli, Gabriela Montandon, Adriano Pimenta, José Bicudo, José Freitas, André Zaharenko and Jan Tytgat
Article: Biochemical and Electrophysiological Characterization of Two Sea Anemone Type 1 Potassium Toxins from a Geographically Distant Population of Bunodosoma caissarum
Mar. Drugs 2013, 11(3), 655-679; doi:10.3390/md11030655
http://www.mdpi.com/1660-3397/11/3/655/
Heidi Hannon and William Atchison
Review: Omega-Conotoxins as Experimental Tools and Therapeutics in Pain Management
Mar. Drugs 2013, 11(3), 680-699; doi:10.3390/md11030680
http://www.mdpi.com/1660-3397/11/3/680/
Zhi-Qiang Xiong, Jian-Feng Wang, Yu-You Hao and Yong Wang
Review: Recent Advances in the Discovery and Development of Marine Microbial Natural Products
Mar. Drugs 2013, 11(3), 700-717; doi:10.3390/md11030700
http://www.mdpi.com/1660-3397/11/3/700/
Xiaohong Wang, Heinz Schröder, Qingling Feng, Florian Draenert and Werner Müller
Review: The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineering: Fabrication of a Morphogenetically-Active Polymer
Mar. Drugs 2013, 11(3), 718-746; doi:10.3390/md11030718
http://www.mdpi.com/1660-3397/11/3/718/
José Vázquez, Isabel Rodríguez-Amado, María Montemayor, Javier Fraguas, María González and Miguel Murado
Review: Chondroitin Sulfate, Hyaluronic Acid and Chitin/Chitosan Production Using Marine Waste Sources: Characteristics, Applications and Eco-Friendly Processes: A Review
Mar. Drugs 2013, 11(3), 747-774; doi:10.3390/md11030747
http://www.mdpi.com/1660-3397/11/3/747/
Zenglei Wang, Hua Tang, Pan Wang, Wei Gong, Mei Xue, Hongwei Zhang, Taofang Liu, Baoshu Liu, Yanghua Yi and Wen Zhang
Article: Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral, Sarcophyton sp.
Mar. Drugs 2013, 11(3), 775-787; doi:10.3390/md11030775
http://www.mdpi.com/1660-3397/11/3/775/
Chi-Jen Tai, Jui-Hsin Su, Chiung-Yao Huang, Ming-Shyan Huang, Zhi-Hong Wen, Chang-Feng Dai and Jyh-Horng Sheu
Article: Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
Mar. Drugs 2013, 11(3), 788-799; doi:10.3390/md11030788
http://www.mdpi.com/1660-3397/11/3/788/
Nils Jansen, Birgit Ohlendorf, Arlette Erhard, Torsten Bruhn, Gerhard Bringmann and Johannes Imhoff
Article: Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550
Mar. Drugs 2013, 11(3), 800-816; doi:10.3390/md11030800
http://www.mdpi.com/1660-3397/11/3/800/
Ganjun Yuan, Kui Hong, Haipeng Lin, Zhigang She and Jia Li
Article: New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
Mar. Drugs 2013, 11(3), 817-829; doi:10.3390/md11030817
http://www.mdpi.com/1660-3397/11/3/817/
Victoria Suárez-Ulloa, Juan Fernández-Tajes, Vanessa Aguiar-Pulido, Ciro Rivera-Casas, Rodrigo González-Romero, Juan Ausio, Josefina Méndez, Julián Dorado and José Eirín-López
Article: The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Mar. Drugs 2013, 11(3), 830-841; doi:10.3390/md11030830
http://www.mdpi.com/1660-3397/11/3/830/
Xiuli Xu, Liyuan Yin, Lijie Gao, Junhai Gao, Junhui Chen, Jingxi Li and Fuhang Song
Article: Two New Bromophenols with Radical Scavenging Activity from Marine Red AlgaSymphyocladia latiuscula
Mar. Drugs 2013, 11(3), 842-847; doi:10.3390/md11030842
http://www.mdpi.com/1660-3397/11/3/842/
M. Rashid, Somayeh Mahdavi and Serdar Kuyucak
Review: Computational Studies of Marine Toxins Targeting Ion Channels
Mar. Drugs 2013, 11(3), 848-869; doi:10.3390/md11030848
http://www.mdpi.com/1660-3397/11/3/848/
Chao-Yan Zhang, Ting Kong, Wen-Hui Wu and Min-Bo Lan
Article: The Protection of Polysaccharide from the Brown Seaweed Sargassum graminifoliumagainst Ethylene Glycol-Induced Mitochondrial Damage
Mar. Drugs 2013, 11(3), 870-880; doi:10.3390/md11030870
http://www.mdpi.com/1660-3397/11/3/870/
María Hortigüela and J. Wall
Article: Improved Detection of Domoic Acid Using Covalently Immobilised Antibody Fragments
Mar. Drugs 2013, 11(3), 881-895; doi:10.3390/md11030881
http://www.mdpi.com/1660-3397/11/3/881/
Yutaka Hata, Shikshya Timalsina and Sainawaer Maimaiti
Review: Okadaic Acid: A Tool to Study the Hippo Pathway
Mar. Drugs 2013, 11(3), 896-902; doi:10.3390/md11030896
http://www.mdpi.com/1660-3397/11/3/896/
Ying-Qing Wang and Ze-Hong Miao
Review: Marine-Derived Angiogenesis Inhibitors for Cancer Therapy
Mar. Drugs 2013, 11(3), 903-933; doi:10.3390/md11030903
http://www.mdpi.com/1660-3397/11/3/903/
Camila Lehnhardt Pires, Selma Rodrigues, Daniel Bristot, Henrique Gaeta, Daniela de Oliveira Toyama, Wladimir Lobo Farias and Marcos Toyama
Article: Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensisPromastigote
Mar. Drugs 2013, 11(3), 934-943; doi:10.3390/md11030934
http://www.mdpi.com/1660-3397/11/3/934/
Maria Serova, Armand de Gramont, Ivan Bieche, Maria Riveiro, Carlos Galmarini, Miguel Aracil, José Jimeno, Sandrine Faivre and Eric Raymond
Article: Predictive Factors of Sensitivity to Elisidepsin, a Novel Kahalalide F-Derived Marine Compound
Mar. Drugs 2013, 11(3), 944-959; doi:10.3390/md11030944
http://www.mdpi.com/1660-3397/11/3/944/
Ling-Yan Dong, Jie Jin, Gao Lu and Xiao-Li Kang
Article: Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress
Mar. Drugs 2013, 11(3), 960-974; doi:10.3390/md11030960
http://www.mdpi.com/1660-3397/11/3/960/
A Marine Animal to Feed Your Eco-Car
Posted On: March 26, 2013The marine animal tunicate can be used both as biofuel and fish food, according to research from Norway. On the ocean floor, under the pier, and on ship ropes — that’s where the tunicates live. Tunicates are marine filter feeders that serve as bacteria eaters and as a foodstuff in Korea and Japan. But in the future they may become more prevalent.
Five researchers at the University of Bergen (UiB) and Uni Research have found that a certain type of tunicate — ascidiacea — can be used as a renewable source of biofuel and fish food. This is particularly good news for the growing aquaculture industry, which for years has struggled to find enough quality feed for its fish. There also is the prospect of reducing emissions from traffic.
Marine bioprospecting – a role for bioresource centers in the 21st century
Posted On: November 19, 2012Marine bioprospecting – a role for bioresource centers in the 21st century. A presentation by Dr Willie Wilson (Director of National Center for Marine Algae and Microbiota, Bigelow Laboratory for Ocean Sciences, USA) presentation at the Oceans of Potential conference, Tuesday 11th September, Plymouth, UK
Mar. Drugs, Volume 10, Issue 8 (August 2012), Pages 1619-1898 Newly Released
Posted On: August 30, 2012MDPI is pleased to announce the publication of the following issue:
Mar. Drugs, Volume 10, Issue 8 (August 2012), Pages Pages 1619-1898
TOC:
Anthony D. Wright, Jonathan L. Nielson, Dianne M. Tapiolas, Catherine H. Liptrot and Cherie A. Motti
Article: A Great Barrier Reef Sinularia sp. Yields Two New Cytotoxic Diterpenes
Mar. Drugs 2012, 10(8), 1619-1630; doi:10.3390/md10081619
http://www.mdpi.com/1660-3397/10/8/1619/
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Daniela Bueno Sudatti, Renato Crespo Pereira, Antonio Alonso, Tania Ueda-Nakamura, Benedito Prado Dias Filho, Celso Vataru Nakamura and Sueli de Oliveira Silva
Article: Trypanocidal Action of (−)-Elatol Involves an Oxidative Stress Triggered by Mitochondria Dysfunction
Mar. Drugs 2012, 10(8), 1631-1646; doi:10.3390/md10081631
http://www.mdpi.com/1660-3397/10/8/1631/
Na Gao, Mingyi Wu, Shao Liu, Wu Lian, Zi Li and Jinhua Zhao
Article: Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea Cucumber
Mar. Drugs 2012, 10(8), 1647-1661; doi:10.3390/md10081647
http://www.mdpi.com/1660-3397/10/8/1647/
Rian J. Meginley, Prasoon Gupta, Thomas C. Schulz, Amanda B. McLean, Allan J. Robins and Lyndon M. West
Article: Briareolate Esters from the Gorgonian Briareum asbestinum
Mar. Drugs 2012, 10(8), 1662-1670; doi:10.3390/md10081662
http://www.mdpi.com/1660-3397/10/8/1662/
Vladimir I. Kalinin, Natalia V. Ivanchina, Vladimir B. Krasokhin, Tatyana N. Makarieva and Valentin A. Stonik
Review: Glycosides from Marine Sponges (Porifera, Demospongiae): Structures, Taxonomical Distribution, Biological Activities and Biological Roles
Mar. Drugs 2012, 10(8), 1671-1710; doi:10.3390/md10081671
http://www.mdpi.com/1660-3397/10/8/1671/
Malcolm W. B. McCulloch, Brad Haltli, Douglas H. Marchbank and Russell G. Kerr
Article: Evaluation of Pseudopteroxazole and Pseudopterosin Derivatives against Mycobacteriumtuberculosis and Other Pathogens
Mar. Drugs 2012, 10(8), 1711-1728; doi:10.3390/md10081711
http://www.mdpi.com/1660-3397/10/8/1711/
Nikolaj G. Vynne, Maria Mansson and Lone Gram
Article: Gene Sequence Based Clustering Assists in Dereplication of Pseudoalteromonas luteoviolacea Strains with Identical Inhibitory Activity and Antibiotic Production
Mar. Drugs 2012, 10(8), 1729-1740; doi:10.3390/md10081729
http://www.mdpi.com/1660-3397/10/8/1729/
Laura Núñez-Pons, Marianna Carbone, Jennifer Vázquez, Jaime Rodríguez, Rosa María Nieto, María Mercedes Varela, Margherita Gavagnin and Conxita Avila
Article: Natural Products from Antarctic Colonial Ascidians of the Genera Aplidium and Synoicum: Variability and Defensive Role
Mar. Drugs 2012, 10(8), 1741-1764; doi:10.3390/md10081741
http://www.mdpi.com/1660-3397/10/8/1741/
Conceição Egas, Miguel Pinheiro, Paula Gomes, Cristina Barroso and Raul Bettencourt
Article: The Transcriptome of Bathymodiolus azoricus Gill Reveals Expression of Genes from Endosymbionts and Free-Living Deep-Sea Bacteria
Mar. Drugs 2012, 10(8), 1765-1783; doi:10.3390/md10081765
http://www.mdpi.com/1660-3397/10/8/1765/
Eliseu Rodrigues, Lilian R. B. Mariutti and Adriana Z. Mercadante
Article: Scavenging Capacity of Marine Carotenoids against Reactive Oxygen and Nitrogen Species in a Membrane-Mimicking System
Mar. Drugs 2012, 10(8), 1784-1798; doi:10.3390/md10081784
http://www.mdpi.com/1660-3397/10/8/1784/
Genoveffa Nuzzo, Maria Letizia Ciavatta, Robert Kiss, Véronique Mathieu, Helene Leclercqz, Emiliano Manzo, Guido Villani, Ernesto Mollo, Florence Lefranc, Lisette D’Souza, Margherita Gavagnin and Guido Cimino
Article: Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites
Mar. Drugs 2012, 10(8), 1799-1811; doi:10.3390/md10081799
http://www.mdpi.com/1660-3397/10/8/1799/
Bárbara Frazão, Vitor Vasconcelos and Agostinho Antunes
Review: Sea Anemone (Cnidaria, Anthozoa, Actiniaria) Toxins: An Overview
Mar. Drugs 2012, 10(8), 1812-1851; doi:10.3390/md10081812
http://www.mdpi.com/1660-3397/10/8/1812/
Shu-Ping Wu, Tsui-Chin Huang, Ching-Chun Lin, Cho-Fat Hui, Cheng-Hui Lin and Jyh-Yih Chen
Article: Pardaxin, a Fish Antimicrobial Peptide, Exhibits Antitumor Activity toward Murine Fibrosarcoma in Vitro and in Vivo
Mar. Drugs 2012, 10(8), 1852-1872; doi:10.3390/md10081852
http://www.mdpi.com/1660-3397/10/8/1852/
Tomohiro Osaki, Kazuo Azuma, Seiji Kurozumi, Yoshimori Takamori, Takeshi Tsuka, Tomohiro Imagawa, Yoshiharu Okamoto and Saburo Minami
Article: Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs
Mar. Drugs 2012, 10(8), 1873-1882; doi:10.3390/md10081873
http://www.mdpi.com/1660-3397/10/8/1873/
Tzu-Rong Su, Feng-Jen Tsai, Jen-Jie Lin, Han Hsiang Huang, Chien-Chih Chiu, Jui-Hsin Su, Ya-Ting Yang, Jeff Yi-Fu Chen, Bing-Sang Wong and Yu-Jen Wu
Article: Induction of Apoptosis by 11-Dehydrosinulariolide via Mitochondrial Dysregulation and ER Stress Pathways in Human Melanoma Cells
Mar. Drugs 2012, 10(8), 1883-1898; doi:10.3390/md10081883
http://www.mdpi.com/1660-3397/10/8/1883/
Aquapharm announces discovery of novel antibiotic compound
Posted On: August 6, 2012Scottish biotechnology company Aquapharm Biodiscovery has discovered a novel antibiotic compound with potent activity against a broad spectrum of multi-drug-resistant Gram-positive bacteria.
The compound, which demonstrates bactericidal potency against Multi Drug Resistant Staphylococcus Aureus (MDRSA) and Multi Drug Resistant Streptococcus Pneumoniae (MDRSP), Clostridium Difficile and Enteroccocus Faecalis which are common causes of death in patients in hospital care units is the company’s first new drug-lead with confirmed in vivo efficacy and commercial potential.
Aquapharm’s ‘AQP-182’ is one of the novel drug-like molecules identified by Aquapharm from its collection of more than 10,000 marine micro-organisms.
The firm has screened a fraction of its collection against selected anti-infective and anti-inflammatory targets, and has already identified 16 molecules of interest.
These include five novel antibiotic compounds comprising two distinct chemical scaffolds that are currently in preclinical development at Aquapharm for the treatment of bacterial infections resistant to existing therapies.
The most advanced of these molecules, according to Aquapharm’s Chief Scientific Officer Dr Tim Morley, is AQP-182 due to its potent activity against multi-drug resistant Gram-positive bacteria with in-vitro minimum-inhibitory-concentrations (MICs) against MDRSA below 0.016ug/ml.
Aquapharm and c-LEcta collaboration on marine-derived biocatalysts
Posted On: July 25, 2012In a pioneering collaboration the leading Scottish biotechnology company Aquapharm and German industrial biotechnology firm c-LEcta are set to fast-track the discovery and commercialisation of a new wave of bio-catalysts.
c-LEcta is skilled in the identification and engineering of enzymes and strains for optimized bio-catalytic industry processes, whilst Aquapharm has proven expertise in harnessing the commercial potential of its unique collection of marine bacteria and fungi.
Together the partners will strengthen and expand their ability to provide innovative solutions across many market areas including production of natural, sustainably produced food, beverage and personal care ingredients.
Mar. Drugs, Volume 10, Issue 6 (June 2012), Pages Pages 1192-1421 Now Available
Posted On: June 26, 2012MDPI is pleased to announce the availability of the following:
Mar. Drugs, Volume 10, Issue 6 (June 2012), Pages Pages 1192-1421
http://www.mdpi.com/1660-3397/10/6/
Table of Contents:
Sheila Marie Pimentel-Elardo, Lubomir Grozdanov, Sebastian Proksch and Ute Hentschel
Article: Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges
Mar. Drugs 2012, 10(6), 1192-1202; doi:10.3390/md10061192
http://www.mdpi.com/1660-3397/10/6/1192/
Shwu-Li Wu, Jui-Hsin Su, Chiung-Yao Huang, Chi-Jen Tai, Ping-Jyun Sung, Chih-Chung Liaw and Jyh-Horng Sheu
Article: Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
Mar. Drugs 2012, 10(6), 1203-1211; doi:10.3390/md10061203
http://www.mdpi.com/1660-3397/10/6/1203/
Sergey A. Dyshlovoy, Sergey N. Fedorov, Anatoly I. Kalinovsky, Larisa K. Shubina, Carsten Bokemeyer, Valentin A. Stonik and Friedemann Honecker
Article: Mycalamide A Shows Cytotoxic Properties and Prevents EGF-Induced Neoplastic Transformation through Inhibition of Nuclear Factors
Mar. Drugs 2012, 10(6), 1212-1224; doi:10.3390/md10061212
http://www.mdpi.com/1660-3397/10/6/1212/
Laura R. Hunt, Stephanie M. Smith, Kelsey R. Downum and Laura D. Mydlarz
Article: Microbial Regulation in Gorgonian Corals
Mar. Drugs 2012, 10(6), 1225-1243; doi:10.3390/md10061225
http://www.mdpi.com/1660-3397/10/6/1225/
Magbubah Essack, Vladimir B. Bajic and John A. C. Archer
Review: Conotoxins that Confer Therapeutic Possibilities
Mar. Drugs 2012, 10(6), 1244-1265; doi:10.3390/md10061244
http://www.mdpi.com/1660-3397/10/6/1244/
Shi-Ming Fang, Cheng-Bin Cui, Chang-Wei Li, Chang-Jing Wu, Zhi-Jun Zhang, Li Li, Xiao-Jun Huang and Wen-Cai Ye
Article: Purpurogemutantin and Purpurogemutantidin, New Drimenyl Cyclohexenone Derivatives Produced by a Mutant Obtained by Diethyl Sulfate Mutagenesis of a Marine-Derived Penicillium purpurogenum G59
Mar. Drugs 2012, 10(6), 1266-1287; doi:10.3390/md10061266
http://www.mdpi.com/1660-3397/10/6/1266/
Shang-Kwei Wang, Shyh-Yueh Puu and Chang-Yih Duh
Article: New 19-Oxygenated Steroids from the Soft Coral Nephthea chabrolii
Mar. Drugs 2012, 10(6), 1288-1296; doi:10.3390/md10061288
http://www.mdpi.com/1660-3397/10/6/1288/
Fuhang Song, Biao Ren, Ke Yu, Caixia Chen, Hui Guo, Na Yang, Hong Gao, Xueting Liu, Mei Liu, Yaojun Tong, Huanqin Dai, Hua Bai, Jidong Wang and Lixin Zhang
Article: Quinazolin-4-one Coupled with Pyrrolidin-2-iminium Alkaloids from Marine-Derived FungusPenicillium aurantiogriseum
Mar. Drugs 2012, 10(6), 1297-1306; doi:10.3390/md10061297
http://www.mdpi.com/1660-3397/10/6/1297/
Xi-Lin Lu, Zhong-Liang Xu, Xiao-Li Yao, Feng-Juan Su, Cheng-Hui Ye, Jing Li, Yong-Cheng Lin, Guang-Lei Wang, Jin-Sheng Zeng, Ru-Xun Huang, Jing-Song Ou, Hong-Shuo Sun, Li-Ping Wang, Ji-Yan Pang and Zhong Pei
Article: Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways
Mar. Drugs 2012, 10(6), 1307-1320; doi:10.3390/md10061307
http://www.mdpi.com/1660-3397/10/6/1307/
Jiun-Yang Chang, Chia-Ching Liaw, Ahmed Eid Fazary, Tsong-Long Hwang and Ya-Ching Shen
Article: New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea
Mar. Drugs 2012, 10(6), 1321-1330; doi:10.3390/md10061321
http://www.mdpi.com/1660-3397/10/6/1321/
Haiyan Shi, Shanjiang Yu, Dong Liu, Leen van Ofwegen, Peter Proksch and Wenhan Lin
Article: Sinularones A–I, New Cyclopentenone and Butenolide Derivatives from a Marine Soft Coral Sinulariasp. and Their Antifouling Activity
Mar. Drugs 2012, 10(6), 1331-1344; doi:10.3390/md10061331
http://www.mdpi.com/1660-3397/10/6/1331/
Ying Zhao, Huan Chen, Zhuo Shang, Binghua Jiao, Bin Yuan, Weizhang Sun, Bingui Wang, Mingyong Miao and Caiguo Huang
Article: SD118-Xanthocillin X (1), a Novel Marine Agent Extracted from Penicillium commune, Induces Autophagy through the Inhibition of the MEK/ERK Pathway
Mar. Drugs 2012, 10(6), 1345-1359; doi:10.3390/md10061345
http://www.mdpi.com/1660-3397/10/6/1345/
Thierry Jauffrais, Jane Kilcoyne, Véronique Séchet, Christine Herrenknecht, Philippe Truquet, Fabienne Hervé, Jean Baptiste Bérard, Cíara Nulty, Sarah Taylor, Urban Tillmann, Christopher O. Miles and Philipp Hess
Article: Production and Isolation of Azaspiracid-1 and -2 from Azadinium spinosum Culture in Pilot Scale Photobioreactors
Mar. Drugs 2012, 10(6), 1360-1382; doi:10.3390/md10061360
http://www.mdpi.com/1660-3397/10/6/1360/
Roberta Teta, Gerardo Della Sala, Barbara Renga, Alfonso Mangoni, Stefano Fiorucci and Valeria Costantino
Article: Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator
Mar. Drugs 2012, 10(6), 1383-1390; doi:10.3390/md10061383
http://www.mdpi.com/1660-3397/10/6/1383/
Takashi Maoka, Harukuni Tokuda, Nobutaka Suzuki, Hideaki Kato and Hideo Etoh
Article: Anti-Oxidative, Anti-Tumor-Promoting, and Anti-Carcinogensis Activities of Nitroastaxanthin and Nitrolutein, the Reaction Products of Astaxanthin and Lutein with Peroxynitrite
Mar. Drugs 2012, 10(6), 1391-1399; doi:10.3390/md10061391
http://www.mdpi.com/1660-3397/10/6/1391/
Anette C. Elde, Ragnhild Pettersen, Per Bruheim, Johanna Järnegren and Geir Johnsen
Article: Pigmentation and Spectral Absorbance Signatures in Deep-Water Corals from the Trondheimsfjord, Norway
Mar. Drugs 2012, 10(6), 1400-1411; doi:10.3390/md10061400
http://www.mdpi.com/1660-3397/10/6/1400/
Banpeng Cao, Haixin Ding, Ruchun Yang, Xiaoji Wang and Qiang Xiao
Communication: Total Synthesis of a Marine Alkaloid—Rigidin E
Mar. Drugs 2012, 10(6), 1412-1421; doi:10.3390/md10061412
http://www.mdpi.com/1660-3397/10/6/1412/
Marine Natural Product Yields Cancer Therapeutic (NCE)
Posted On: June 13, 2012SIO scientists have mined their rare collection of marine organisms to identify, characterize and analog a proprietary, small molecule with anti-cancer properties. SAR studies have identified regions of the molecule that have yielded analogs of greatest interest. Compositions of matter and methods of use are claimed for the treatment of cancer and hyperproliferative disorders.
SUGGESTED USES
While in vivo studies have not confirmed which drugs will be most useful for which cancers, studies suggest the first targets may be solid tumors, particularly colon cancer. In general, any disease or condition characterized by hyperproliferative cell growth may benefit from this therapeutic approach.
Toxins from algae prove in demand
Posted On: April 24, 2012Nelson’s Cawthron Institute has broken into an international market selling minute quantities of organic compounds sourced from algae and worth 50,000 times the price of gold.
A level teaspoon of the compounds was worth several million dollars, acting chief executive Daryl Wehner said today.
“Our sales over the first nine months have exceeded a quarter of a million dollars and we have several large orders already placed awaiting delivery,” he said.
The compounds, natural toxins produced by algae, often found in food such as shellfish, are necessary for research and other high value products, including pharmaceuticals, making them of special interest to scientists working in these fields, as well as regulatory bodies.
Cawthron is one of only a handful of organisations worldwide with the capability to produce these rare naturally occurring compounds to the market.
Marine Drugs Announces New Issue: Mar. Drugs, Volume 10, Issue 3
Posted On: March 23, 2012MDPI recently announced the publication of the following issue:
Mar. Drugs, Volume 10, Issue 3 (March 2012), Pages Pages 521-676
http://www.mdpi.com/1660-3397/10/3/
Table of Contents:
Jing Tong, Hank Trapido-Rosenthal, Jun Wang, Youwei Wang, Qing X. Li and Yuanan Lu
Article: Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters
Mar. Drugs 2012, 10(3), 521-538; doi:10.3390/md10030521
http://www.mdpi.com/1660-3397/10/3/521/
Li Sun, Dongli Li, Meihua Tao, Yuchan Chen, Feijun Dan and Weimin Zhang
Article: Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26
Mar. Drugs 2012, 10(3), 539-550; doi:10.3390/md10030539
http://www.mdpi.com/1660-3397/10/3/539/
Zeping Xie, Bing Liu, Hongpeng Wang, Shengxiang Yang, Hongyu Zhang, Yipeng Wang, Naiyun Ji, Song Qin and Hartmut Laatsch
Article: Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
Mar. Drugs 2012, 10(3), 551-558; doi:10.3390/md10030551
http://www.mdpi.com/1660-3397/10/3/551/
Yun-Jing Chai, Cheng-Bin Cui, Chang-Wei Li, Chang-Jing Wu, Cong-Kui Tian and Wei Hua
Article: Activation of the Dormant Secondary Metabolite Production by Introducing Gentamicin-Resistance in a Marine-Derived Penicillium purpurogenum G59
Mar. Drugs 2012, 10(3), 559-582; doi:10.3390/md10030559
http://www.mdpi.com/1660-3397/10/3/559/
Danielle F. Mello, Eliza S. de Oliveira, Renato C. Vieira, Erik Simoes, Rafael Trevisan, Alcir Luiz Dafre and Margherita Anna Barracco
Article: Cellular and Transcriptional Responses of Crassostrea gigas Hemocytes Exposed in Vitro to Brevetoxin (PbTx-2)
Mar. Drugs 2012, 10(3), 583-597; doi:10.3390/md10030583
http://www.mdpi.com/1660-3397/10/3/583/
Yan-Bo Zeng, Hui Wang, Wen-Jian Zuo, Bo Zheng, Tao Yang, Hao-Fu Dai and Wen-Li Mei
Article: A Fatty Acid Glycoside from a Marine-Derived Fungus Isolated from Mangrove PlantScyphiphora hydrophyllacea
Mar. Drugs 2012, 10(3), 598-603; doi:10.3390/md10030598
http://www.mdpi.com/1660-3397/10/3/598/
Nicolantonio D’Orazio, Eugenio Gemello, Maria Gammone, Massimo de Girolamo, Cristiana Ficoneri and Graziano Riccioni
Review: Fucoxantin: A Treasure from the Sea
Mar. Drugs 2012, 10(3), 604-616; doi:10.3390/md10030604
http://www.mdpi.com/1660-3397/10/3/604/
Wan-Yu Lin, Yi Lu, Bo-Wei Chen, Chiung-Yao Huang, Jui-Hsin Su, Zhi-Hong Wen, Chang-Feng Dai, Yao-Haur Kuo and Jyh-Horng Sheu
Article: Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft CoralSarcophyton crassocaule
Mar. Drugs 2012, 10(3), 617-626; doi:10.3390/md10030617
http://www.mdpi.com/1660-3397/10/3/617/
Hou-Jin Li, Ying-Lu Xie, Zhong-Liang Xie, Ying Chen, Chi-Keung Lam and Wen-Jian Lan
Article: Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated FungusChondrostereum sp.
Mar. Drugs 2012, 10(3), 627-638; doi:10.3390/md10030627
http://www.mdpi.com/1660-3397/10/3/627/
Min-Juan Xu, Xiao-Jin Liu, Yi-Lei Zhao, Dong Liu, Zhen-Hao Xu, Xiao-Meng Lang, Ping Ao, Wen-Han Lin, Song-Lin Yang, Zhi-Gang Zhang and Jun Xu
Article: Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis
Mar. Drugs 2012, 10(3), 639-654; doi:10.3390/md10030639
http://www.mdpi.com/1660-3397/10/3/639/
Yuta Kudo, Takeshi Yasumoto, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
Article: Isolation and Structural Determination of the First 8-epi-type Tetrodotoxin Analogs from the Newt, Cynops ensicauda popei, and Comparison of Tetrodotoxin Analogs Profiles of This Newt and the Puffer Fish, Fugu poecilonotus
Mar. Drugs 2012, 10(3), 655-667; doi:10.3390/md10030655
http://www.mdpi.com/1660-3397/10/3/655/
Zhuang Han, Ying Xu, Oliver McConnell, Lingli Liu, Yongxin Li, Shuhua Qi, Xiangzhong Huang and Peiyuan Qian
Article: Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus
Mar. Drugs 2012, 10(3), 668-676; doi:10.3390/md10030668
http://www.mdpi.com/1660-3397/10/3/668/
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