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MDPI announces publication of new Marine Drugs issue: Volume 9, Issue 3

Admin — Fri, 25 Mar 2011 19:26:53 +0000

MDPI announces publication of the following issue:

Mar. Drugs, Volume 9, Issue 3 (March 2011), Pages 294-477 http://www.mdpi.com/1660-3397/9/3/

Table of Contents:

Article: Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats Mar. Drugs 2011, 9(3), 294-306; doi:10.3390/md9030294

http://www.mdpi.com/1660-3397/9/3/294

Article: Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa Mar. Drugs 2011, 9(3), 307-318; doi:10.3390/md9030307

http://www.mdpi.com/1660-3397/9/3/307

Review: Marine Carotenoids: Biological Functions and Commercial Applications Mar. Drugs 2011, 9(3), 319-333; doi:10.3390/md9030319

http://www.mdpi.com/1660-3397/9/3/319

Article: Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San AndrC)s and Providencia Islands (Southwest Caribbean Sea) Mar. Drugs 2011, 9(3), 334-344; doi:10.3390/md9030334

http://www.mdpi.com/1660-3397/9/3/334

Article: Dynamics of Dissolved and Particulate Polyunsaturated Aldehydes in Mesocosms Inoculated with Different Densities of the Diatom Skeletonema marinoi Mar. Drugs 2011, 9(3), 345-358; doi:10.3390/md9030345

http://www.mdpi.com/1660-3397/9/3/345

Article: Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17 Mar. Drugs 2011, 9(3), 359-368; doi:10.3390/md9030359

http://www.mdpi.com/1660-3397/9/3/359

Article: Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites Mar. Drugs 2011, 9(3), 369-381; doi:10.3390/md9030369

http://www.mdpi.com/1660-3397/9/3/369

Article: An Acetylenic Alkaloid from the Calcareous Sponge Leucetta sp.

Mar. Drugs 2011, 9(3), 382-386; doi:10.3390/md9030382

http://www.mdpi.com/1660-3397/9/3/382

Review: Mycosporine-Like Amino Acids: Relevant Secondary Metabolites. Chemical and Ecological Aspects Mar. Drugs 2011, 9(3), 387-446; doi:10.3390/md9030387

http://www.mdpi.com/1660-3397/9/3/387

Review: Astaxanthin: A Potential Therapeutic Agent in Cardiovascular Disease Mar. Drugs 2011, 9(3), 447-465; doi:10.3390/md9030447

http://www.mdpi.com/1660-3397/9/3/447

Article: Preparation of Calibration Standards of N1-H Paralytic Shellfish Toxin Analogues by Large-Scale Culture of Cyanobacterium Anabaena circinalis (TA04) Mar. Drugs 2011, 9(3), 466-477; doi:10.3390/md9030466

http://www.mdpi.com/1660-3397/9/3/466

New Publication Details Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge

Admin — Fri, 04 Mar 2011 17:21:11 +0000

Leiodermatolide is a structurally unique macrolide isolated from the deep-water marine sponge Leiodermatium sp. which exhibits potent antiproliferative activity against a range of human cancer cell lines and drastic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational NMR methods.

Paterson, I., Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzmán, E. A., Isbrucker, R., Pitts, T. P., Linley, P., Divlianska, D., Reed, J. K. and Wright, A. E. , Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.Angewandte Chemie International Edition, n/a. doi: 10.1002/anie.201007719

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Sponge Genome Reveals Animal, Cancer Origins

Admin — Fri, 06 Aug 2010 14:38:43 +0000

In a paper appearing in the recent issue of the journal Nature, a team of researchers led by Daniel Rokhsar of the Univ. of California, Berkeley, and the Department of Energy’s Joint Genome Institute (JGI), report the draft genome sequence of the sea sponge Amphimedon queenslandica and several insights the genome gives into the origins of both the first animals and cancer.

“Our hypothesis is that multicellularity and cancer are two sides of the same coin,” says Rokhsar, professor at UC Berkeley. “If you are a cell in a multicellular organism, you have to cooperate with other cells in your body, making sure that you divide when you are supposed to as part of the team. The genes that regulate this cooperation are also the ones whose disruption can cause cells to behave selfishly and grow in uncontrolled ways to the detriment of the organism.”

As part of the new analysis, the team looked in the sponge genome for more than 100 genes that have been implicated in human cancers and found about 90 percent of them. Future research will show what roles these genes play in endowing sponge cells with team spirit.

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New Activity Found For A Potential Anti-cancer Agent From Marine Sponges

Admin — Wed, 11 Nov 2009 19:34:10 +0000

Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That’s the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product.

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